Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2014
Student: İRFAN KENAN
Supervisor: EMİNE BELGİN KOÇER
Abstract:Multiple sclerosis (MS) is a chronic disease that is characterized by inflammation, demyelinating, axonal loss and astrogliosis with a white matter involvement primarily, focal inflamatuar-demyelinating plaques, which could affect cortex and deep gray matter. MS is the most disabiling neurological disorder in young adult populations in the developed countries. MRG (magnetic resonance imaging), cerebrospinal fluid (BOS) examinations and evoked potentials (EP) were used as supporting diagnostic methods. In differential diagnosis of MS, it should be taken into account genetic, infectious, inflammatuar, metabolic, autoimmune and neuroplastic diseases retaining central nervous system. In the present study, it was aimed to examine the relation of autoimmunoantibodies with the presence of oligoclonal band and IgG index increase visual evoked potentials (VEP), posterior tibial somatosensory evoked potentials (SEP) and auditory evoked potentials (BAEP) abnormality in clinical, brain and spinal magnetic resonance imaging and cerebrospinal fluid in the cases with clinical isolated syndrome, relapsing-remitting and secondary progressive multiple sclerosis applying to Gazi University Medical Faculty Neurology Department between 2010-2013, In MRI, the numbers of lesions in relation to autoantibody at basal, 6th month and 2nd year were compared. In this study, it was found that duration of the disease were shorter and EDSS score were lower in KIS patients comparing to MS patients (p;0.00). It was detected that in 13 of KIS patients (54,2%), in 22 of MS patients (39,2%) autoantibodies were found as positive. In both groups mostly ANA positivity were detected (p;0.252). When the 6th month and 2nd year follow up MRG findings of patients with autoimmune positivity and negativity were examined, no increase were detected (for MS p=1-0.576, for KISp=0.124-0.571). In the examination of thoracal and cervical MRG, any significant differences were found ( p>0.05). Having not found any significant differences in electrophysiological and MRI parameters in KIS and MS patients with positive and negative autoimmune have shown that autoimmunoantibodies caused no differences between two disorders in terms of prognosis and follow up.