Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2017
Student: ZEYNEP ÇAVDAR
Supervisor: NURİYE EBRU ERGENEKON
Abstract:UA (uric acid) is the last product of purine catabolism. Premature babies may have high uric acid levels due to low urine output and tissue destruction during the first days of life. UA is part of antioxidant systems in the body. Increased uric acid in the serum can be positive for the baby. However, high values are usually treated with a xanthine oxidase inhibitor as they may impair renal function. In this study, it was aimed to investigate retrospectively whether there is an association between increased uric acid level and early morbidity in premature infants in the first days of life. For this purpose, 68 premature infants who were admitted to our neonatal intensive care unit within 2 years and whose birth week was 32 weeks or less were retrospectively studied. Maternal risk factors, gestational age, birth weight (DA), APGAR scores, initial pH and baseline values, 2nd day BUN, UA values, mechanical ventilation, CPAP, oxygen therapy durations, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), retinopathy of prematurity (PR), seizure, necrotizing enterocolitis (NEC) were recorded. Infants whose uric acid level was lower or higher than 6.5 mg / dl were evaluated for the frequency of morbidity. Gestation age: 29,8 ± 2 weeks, birth weight: 1343 ± 502 g, BUN: 15,8 ± 5,4, uric acid: 6,3 ± 2,2 mg / dl There was no difference between groups in terms of gestational age and birth weight. In the group with high uric acid levels, APGAR scores were found to be lower and BUN values were found to be higher, although not statistically significant. When evaluated in terms of early neonatal morbidity, there was a significant difference in BPD and seizure development between UA low and high group. BPD: uric acid 10% in low group, uric acid 40% in high group p = 0.005, seizure: uric acid in low group 2%, uric acid in high group 23% p = 0.003. These results suggest that serum UA values may help predict early neonatal morbidity, such as BPD and seizures. No significant difference was found between logistic regression analysis and other risk factors and these morbidities