New aminoacid -schiff bases and Ni(II) complexes synthesis, characterization and evaluation of biological activity

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Thesis Type: Postgraduate

Institution Of The Thesis: Gazi Üniversitesi, Fen Bilimleri Enstitüsü, Turkey

Approval Date: 2011

Student: NİHAT PİŞKİN

Supervisor: NURŞEN SARI

Open Archive Collection: AVESIS Open Access Collection

Abstract:

In this study, by using 5- Floro- Salisilaldehyde and 5- Floro 3- Chloride Salisilaldehyde with D-glycine and D-alanine, Schiff bases and their Ni(II) complexes were prepared. Characterization and biological activities were evaluated. The structure and element analysis of Schiff bases and Ni (II) complexes are lightened by using FTIR, 1H-NMR, 13C-NMR and UV- GB spectras. In the all complexes, the Schiff bases act as three dentate chelate connecting to Ni(II) ion from imine nitrogen, carbonyl oxygen and hydroxyl oxygen. The result of it, Ni(II): L ratio 1:1 was foreseen. Schiff base complexes prepared by 5 - Floro - Salisilaldehyde were foreseen square planar structure. The biological activities of amino acid - Schiff bases and their Ni(II) complexes were evaluated against Staphylococcus aureus (RSKK-07035), Escherichia coli (ATCC-1230), Salmonella typhi H (NCTC- 901.8394), Brucella abortus (RSKK-03026), Micrococcus luteus, Listeria monocytogenes 4b (ATCC 19115), Staphylococcus epidermidis, Sh.dys. typ 10 and Candida albicans (Y-1200-NIH) used as a yeast, Tokyo