Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, FARMAKOGNOZİ ANABİLİM DALI, Turkey
Approval Date: 2021
Thesis Language: Turkish
Student: Özge Sultan PINARBAŞI
Supervisor: Esra Akkol
Abstract:
There are 3 genera and about 45 species, including Hippophae, Shepherdia and Elaeagnus in the Elaeagnaceae family, which spreads in Asian, European and North American steppe regions and rocky places. Two species, Hippophae rhamnoides and Elaeagnus angustifolia, grow in our country. Due to the widespread distribution of species belonging to the Elaeagnaceae family in the world and in Turkey, it is seen that they are widely used among the people and in traditional medicine. In ethnobotanical field studies conducted in our country, it has been determined that the fruits of E. angustifolia are used as antipyretic, urolithiatic, antidiarrheal and anti-inflammatory in eye effects in Central Anatolia. In this study, it was aimed to evaluate the anti-inflammatory activity of different polarity extracts prepared from the leaves, branches and fruits of E. angustifolia, which is widely distributed in our country and used in folk medicine, by in vitro methods. The anti-inflammatory effect of n-hexane, ethyl acetate and methanol extracts prepared from the plant was evaluated by performing in vitro cyclooxygenase (COX-1 and COX-2) enzyme inhibition, inhibition of protein denaturation, proteinase enzyme inhibition and anti-lipoxygenase activity tests. Results of the study showed that the ethyl acetate extract prepared from the stems had the highest activity. It was concluded that the data obtained in this context supports the use of the plant among the people.
Key Words
Ethnobotany, Elaeagnaceae, Elaeagnus angustifolia, Phtotherapy, Anti-inflammatory