Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi University, Fen Bilimleri Enstitüsü, Turkey
Approval Date: 2022
Thesis Language: Turkish
Student: Enis Taha ÖZKAN
Supervisor: Yusuf Kalender
Open Archive Collection: AVESIS Open Access Collection
Abstract:
Fenitrothion is an organophosphate insecticide that is frequently used against agricultural pests. Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally occurring phenolic compound in some plants. Pesticides cause an increase in reactive oxygen species and the formation of free radicals in cells and tissues. In this study, the protective effects of gallic acid on fenitrothion induced testicular toxicity in rats were investigated. In the study, rats were divided into four groups: The 1st group: control group, the 2nd group: gallic acid (50 mg/kg/day) treated group, the 3rd group of phenitrothione (32 mg/kg/day) treated group, the 4th group of fenitrothion (32 mg/kg/day) and gallic acid (50 mg /kg/day) treated groups. After 28 days of treated, malondialdehyde (MDA) levels and antioxidant enzyme [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST)] activities and histopathological changes in rat testis tissues examined. While fenitrothion caused an increase in the MDA level in testicular tissue of rats, it caused a decrease in antioxidant enzyme activities (SOD, CAT, GST, GPx). Gallic acid reduced the oxidative stress caused by fenitrothion. In histopathological examinations, fenitrothion caused a decrease in the number of spermatogenic cells in rat testes, disruption of the basement membrane, and necrosis in some seminiferous tubules. Gallic acid reduced the pathological changes in rat testes.
Key Words : Fenitrothion, Gallic acid, Histopathology, Oxidative stress, Antioxidant enzymes