Toxıc Effect Of Lead Nıtrate And Cadmıum Chlorıde On Rat Lung Tıssue And The Protectıve Role Of Sesamole

Thesis Type: Postgraduate

Institution Of The Thesis: Gazi University, Sağlık Hizmetleri Meslek Yüksekokulu, Sağlık Bakım Hizmetleri, Turkey

Approval Date: 2022

Thesis Language: Turkish


Principal Supervisor (For Co-Supervisor Theses): Yusuf Kalender

Co-Supervisor: Meltem Uzunhisarcıklı


Lead and cadmium are toxic heavy metals that adversely affect people's health. Sesamol is a phytochemical found in sesame oil and has antioxidant properties. In this study, lead nitrate (90 mg/kg/day), cadmium chloride (3 mg/kg/day), lead nitrate+cadmium chloride, sesamol (50 mg/kg/day), lead nitrate+sesamol, cadmium chloride+sesamol and lead nitrate+cadmium chloride+sesamol were administered to male rats by gavage once a day for 28 days. At the end of 28 days, malondialdehyde (MDA) levels and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities and histopathological changes were investigated in lung tissue of rats. A statistically significant decrease in antioxidant enzyme activities and an increase in MDA levels were detected in lead nitrate and cadmium chloride treated groups compared to the control group. When the groups treated with lead nitrate, cadmium chloride and sesamol were compared to cadmium chloride, lead nitrate, lead nitrate+cadmium chloride treated groups, a statistically significant increase in antioxidant enzyme activities and a significant decrease in MDA levels were detected. Lead nitrate and cadmium chloride caused cell infiltration in the lung tissue of rats, thickening of the interalveolar septum, alveolar dilatation, and histopathological changes such as degeneration in the bronchial epithelium. Sesamol caused improvement in lung tissue, MDA level, antioxidant enzyme activities and histopathological changes.


Key Words


Cadmium chloride, lead nitrate, sesamol, lung, oxidative stress,