Research Information System
Thesis Type: Doctorate
Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, ÇOCUK DİŞ HEKİMLİĞİ ANA BİLİM DALI, Turkey
Approval Date: 2021
Thesis Language: Turkish
Student: İlayda HÜNLER DÖNMEZ
Supervisor: Cengiz Haluk Bodur
Open Archive Collection: AVESIS Open Access Collection
Abstract:
In this thesis; antimicrobial efficiency of stone water (Kale Natural, Balıkesir, Turkey), pine
turpentine essence (Ali Ünyazıcı, Ankara, Turkey), olive leaf extract (Kale Natural, Balıkesir,
Turkey), grape seed oil (Ali Ünyazıcı, Ankara, Turkey), coconut oil (Ali Ünyazıcı, Ankara,
Turkey), propolis (Bee'o Up, Istanbul, Turkey), tea tree oil (Ali Ünyazıcı, Ankara, Turkey),
pine bark extract (Kale Natural, Balıkesir, Turkey), 2% chlorhexidine (Drogsan, Ankara,
Turkey), glycerol and distilled water on Enterococcus faecalis (E. faecalis, ATCC#29212),
Streptococcus mutans (S. mutans ATCC#25175), Lactobacillus acidophylus (L.
acidophylus ATCC#4356) and Candida albicans (C. albicans ATCC#10231) were
investigated. Disc diffusion and well diffusion methods were repeated three times, and
microdilution test was studied with natural products that showed efficacy. Among the groups
formed by natural products, preparations with antimicrobial effect and chlorhexidine
digluconate group were included in the statistical analysis. The conformity of the data to the
normal distribution was examined by the Shapiro-Wilk test and the compatibility to the
homogeneity assumption with the Levene test, the Kruskal Wallis test was used as the
analysis method. Dunn's test was used as an advanced test in order to reveal the groups
with differences. The p0.05 criterion was taken as a basis in the evaluation of the
mentioned statistical methods, and SPSS 26 and R Studio package programs were used
in the application of the tests. As a result of the study, pine turpentine, propolis, tea tree oil
and red pine bark extract; showed antimicrobial activity against oral pathogens used. Tea
tree oil showed the highest antimicrobial activity against C. albicans and was significantly
more anticandidal than 2% chlorhexidine digluconate. Although pine turpentine, propolis,
tea tree oil and red pine bark extract showed activity against L. acidophylus, it did not show
antibacterial properties as high as 2% chlorhexidine digluconate. It was concluded that
natural products are as antimicrobial as chlorhexidine against S. mutans and E. faecalis.
Key Words : Natural Product, Phytotherapy, Essential Oils, Antimictobial,
Oral Pathogens