Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi University, Turkey
Approval Date: 2016
Thesis Language: Turkish
Student: Nigar Mammadova
Supervisor: BAHRİ AYDIN
Abstract:Purpose: The aim of this study is to evaluate the reliability of endolaser photocoagulation of 532 nm laser system produced by Omesis Medikal, by detecting the effects of endolaser photocoagulation of different laser devices on retina and provide production of new local devices. Materials and Methods: 532 nm diode laser photocoagulation device was produced by Omesis company before animal study. Twelve pigmented rabbits were divided into 2 groups, named OMESIS and DORC. Each group is divided to two sub-groups, which are defined as early and late period. Pars plana 20 gauge triport entry performed 1,5 mm behind the limbus, and core vitrectomy was applied. After core vitrectomy, 100-200 shots of retinal photocoagulation with 100 mW power and 0,1 second interval was applied as one spot interval that comprise white spots to the retina layers locating under the visual line of right eyes of 6 rabbits in the first group by using Omesis device and right eyes of 6 rabbits in the second group using laser of DORC company (as a control). Enucleation was applied to the two of the rabbits in both OMESIS and DORC groups immediately after the process (early period) and to the right eyes of the remaining four rabbits after 2 weeks (late period) in each group following after euthanasia. Axial sections were captured below the visual line. 20 mm sections were histologically examined with hematoxylin eosin and toluidine blue stains.Results: It was observed that, similar laser burns were formed in both DORC, which has been used as a standard control group, and Omesis group during the process. Histologically in haematoxylin and eosin stains, there is cohesiveness between retina, retina pigment epithelium and choroid, and retinoschisis, and subretinal fluid around laser burns in both OMESIS and DORC groups, similarly. No histologic difference was identified between OMESIS and DORC laser burns in the early period and late samples. Discussion and Conclusion: It will be possible to introduce internationally competent products in the area of retinal laser applications by integration of slit lamp biomicroscopes into OMESIS laser system, implementation of pattern laser, micropulse laser and new applications. This will also bring recognition to our national scientists world wide. Retinal photocoagulation burns by OMESIS laser are morphologically and histologically similar to DORC laser photocoagulation. No complications were observed during photocoagulation by both laser systems. This fact shows effectiveness and reliability of OMESIS laser system. Based on experiments on rabbit eyes, OMESIS laser system seems to be a reliable alternative for retinal photocoagulation.