Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi University, Fen Bilimleri Enstitüsü, Turkey
Approval Date: 2019
Thesis Language: Turkish
Student: SELİNAY ÖZEL
Supervisor: Yılmaz Yıldırır
Abstract:
Cancer is the uncontrolled or abnormal growth and proliferation of cells as a result of damage
to DNA. The treatment process is not easy and chemotherapy applied for treatment has many
side effects. For these reasons, new treatment methods are being investigated. Recent studies
have shown that flavonoids have the potential to be used in cancer treatment. Due to these
properties, flavonoids have attracted the attention of scientists and have led to an increase in
studies on their mechanism of action, their contribution to the treatment process and their
functions in metabolic reactions. The synthesis of such structures is very important because
they are found very low amount in plants and large quantities of plants are needed even for
a single dose of drug. Researchs show that among more than 6000 flavonoids discovered to
date, apigenin and quercetin are the most promising substances for cancer treatment. In this
research, it was aimed to synthesize apigenin and quercetin derivatives have trifluoromethyl
groups containing fluorine atoms that can make strong hydrogen bonds because of apigenin
and quercetin interact with the receptor by hydrogen bonds. These substances are expected
to have higher bioactivity against cancer cells. The structures of the synthesized compounds
were elucidated using ATR-FTIR, 1H-NMR, 13C-APT NMR and LC-MS spectroscopy
techniques.