Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2008
Student: SENA IRMAK
Supervisor: AYMELEK GÖNENÇ
Abstract:In our study, serum MDA, TAC, nitrite + nitrate, homocysteine, B9 , B12, HDL-cholesterol, VLDL- cholesterol, LDL-cholesterol, total cholesterol and triglyceride levels of 90 patients diagnosed for vascular congestion after angio and 32 healthy people were tested. Additionally, effects of factors such as gender, age, quatelet index, smoking habit, physical exercise, dietary habits, history of families and diagnosed diseases were statistically evaluated for all the subjects. The levels of MDA and nitrite + nitrate levels of total patient group were found to be statistically higher than of the control group (p<0.01), TAC and B12 levels were found to be statistically lower than of the control group (p<0.01). The levels of MDA of the patient group with minimal vascular damage were found to be statistically higher than of the control group (p<0.01), B12 levels were found to be statistically lower than of the control group (p<0.01). The levels of nitrite + nitrate and homocysteine of the patient group with one-vessel were found to be statistically higher than of the control (p<0.01) and B12 levels were found to be statistically lower than of the control (p<0.01). The levels of MDA and nitrite + nitrate of the patient group with two-vessels were found to be statistically higher than of the control group (p<0.01), TAC levels were found to be statistically lower than of the control group (p<0.01). Also the levels of MDA and nitrite + nitrate of the patient group with three-vessels were found to be statistically higher than of the control group (p<0.01), TAC levels were found to be statistically lower than of the control group (p<0.01). MDA, nitrite + nitrate and homocysteine levels of the patient group with minimal vascular damage were found to be statistically higher than of the patient group with one-vessel (p<0.01). The levels of MDA and nitrite + nitrate of the group with minimal vascular damage were found to be statistically higher than of the patient group with two-vessels (p<0.01), TAC levels were found to be statistically lower (p<0.01). The levels of MDA and nitrite + nitrate of the patient group with minimal vascular damage were found to be statistically higher than of the patient group with three-vessels (p<0.01), TAC levels were found to be statistically lower (p<0.01). MDA levels of group by one-vessel were found to be statistically lower than the group with two-vessels (p<0.01), B12 and TAC levels were found to be statistically higher (p<0.01). The levels of MDA of the patient group with one-vessel were found to be statistically lower than of the patient group with three-vessels (p<0.01), TAC levels were found to be statistically higher (p<0.01). While the levels of MDA and nitrite + nitrate of the patient group with two-vessels were found to be statistically lower than of the patient group with three-vessels (p<0.01), TAC levels were found to be statistically higher (p<0.01). The levels of HDL-cholesterol and LDL-cholesterol of total patient group were found to be statistically higher than of the control group (p<0.01); but no significant differences found with VLDL- cholesterol, total cholesterol and triglyceride levels (p>0.05). The levels of HDL-cholesterol of the patient groups were found to be statistically different (p<0.01), however the relation between VLDL- cholesterol, total cholesterol, LDL-cholesterol and triglyceride levels was found to be statistically non significant (p>0.05). When total patient and the control group was compared according to gender, age, quatelet index, physical exercise, dietary habits and familial narrative; the relation between MDA, TAC, nitrite + nitrate, homocysteine, B9 and B12 vitamin levels were found to be statistically significant (p<0.01). According to the smoking habit, the levels of TAC and nitrite + nitrate of the patient group were found to be statistically higher than of the control group (p<0.01). Considering to the age factor, the levels of TAC, nitrite + nitrate and B12 of the patients over 55 years were found to be statistically higher than of the patients below 55 years (p<0.01). While the gender factor compared, the levels of TAC and B12 in women were found to be statistically lower than of the men (p<0.01), the relation of the levels in men was found to be statistically non significant (p>0.05). Significant correlations were found between TAC and MDA in total patient group (p<0.01). Significant correlations were found between nitrite+ nitrate and TAC in minimal vascular damage (p<0.01). Significant correlations were found between homocysteine and MDA in one-vessel (p<0.05). Significant correlations were found between nitrite+ nitrate and MDA in two-vessels (p<0.01). Significant correlations were found between nitrite+ nitrate and TAC (p<0.01), homocysteine and nitrite+ nitrate in three-vessels (p<0.01).