Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi University, Tıp Fakültesi, Turkey
Approval Date: 2014
Thesis Language: Turkish
Student: NESİBE CESUR
Supervisor: İpek Işık Gönül
Open Archive Collection: AVESIS Open Access Collection
Abstract:Gene fusions are the most genetic alterations in prostate cancers. In 2003, Vanaja et al. first reported the over-expression of the oncogene ERG at the transcript level in 50 % of clinically localized and metastatic prostate cancer samples. TMPRSS2- ERG gene fusion is the most common ERG-related gene fusion (%90) and is between ERG oncogene- localised at chromosome 21q22.3- and androgen- regulated TMPRSS2 gene. In this study, we evaluated expression of ERG in 136 prostate cancer patients who underwent radical prostatectomy. We graded the tumors according to the update Gleason grading system and noted the presence of HG-PIN. Staining extensity of ERG in prostatic adenocarcinoma and HG-PIN was 63.23 % and 31.81 consecutively. The highest staining extensity was present in GS 6 and GS 7 prostatic adenocarcinomas. Non-neoplastic prostatic tissue did not exhibit ERG expression at the protein expression level. In conclusion, ERG expression can be used for seperating non-neoplastic, preneoplastic and neoplastic prostatic lesions. At tumour negative needle biopsies, ERG positivity may be the sign for the presence of a tumour in a given patient.