Determination of Levels cytokeratin 18 in chronic pancreatitis

Thesis Type: Expertise In Medicine

Institution Of The Thesis: Gazi University, Turkey

Approval Date: 2014

Thesis Language: Turkish

Student: Teoman Şakalar



Introduction and aims: Chronic pancreatitis (CP) is a inflammatory disease that leading to morphological changes, , permanent destruction, fibrosis in pancreas with endocrine and exocrine functional impairment. İnflammation, fibrosis and apoptosis plays role in the pathogenesis of the disease. Cytokeratins compose the intermediate filament cytoskeleton of epithelial cells. Cytokeratin functions are maintain cell shape, motility, and cell-cell interactions. Cytokeratin 18 is synthesized bladder epithelium, colonic mucosa, hepatocytes, pancreatic acinar cells of various tissues. Several studies showed that cytokeratin 18 have a role in apoptosis and can be use as a marker of apoptosis. The aim of this study is to determine relationship between chronic pancreatitsn and cytokeratin 18 . Materials and Methods: 35 chronic pancreatitis patients and 35 healthy volunteers were enrolled for the study. Blood samples for cytokeratin 18 tests were taken after 12 h fasting. Relationship between chronic pancreatin and cytokeratin 18 were evaluated. Results: The mean levels of cytokeratin 18 were 0.45 ± 1.40 ng / ml in patients with chronic pankreatits and the mean levels of cytokeratin 18 were 0.16 ± 0.16 ng / ml in the control group. There was no statistically association between chronic pancreatits and cytokeratin 18 . Discussion and Conclution:. The role of apoptosis in the pathogenesis of chronic pankreatitis well known situation but in this study there was no statistically association between chronic pancreatitis and cytokeratin 18 which is the marker of apoptosis. We showed that cytokeratin is not a reliable marker for the diagnosis and fallow up of chronic pancreatitis and additional studies are needed to show new markers for diagnosis and fallow up of chronic pancreatitis