Research Information System
Thesis Type: Doctorate
Institution Of The Thesis: Gazi University, Turkey
Approval Date: 2015
Thesis Language: Turkish
Student: Elifcan Kıvrak
Supervisor: GÜLAY TÜTER
Abstract:Cathelicidin LL-37, an antimicrobial peptide, is part of the host innate immune response in the oral cavity. The aims of this study are to evaluate; gingival crevicular fluid (GCF) levels of LL-37 and serum vitamin D3 levels and clinical parameters in smoker and nonsmoker patients with chronic periodontitis. Plaque index (PI), gingival index (GI), probing depth (PD) and clincal attachment level (CAL) measurements, GCF and blood serum samples were collected from smoker (n:20) and non-smoker (n:20) patients with chronic periodontitis and periodontally healthy (n:20) control subjects at baseline. GCF levels of LL-37 were measured by ELISA and serum levels of vitamin D3 were analysed by High-performance liquid chromatography (HPLC). Statistical analysis were performed. GCF levels of LL-37 have been found significantly higher in chronic periodontitis groups than control subjects but no significant difference was found between smoking and nonsmoking periodontitis groups (p<0.05). There was a positive correlation between GCF LL-37 and vitamin D levels in smoker chronic periodontitis group (p<0.01). All clinical parameters were found correlated with GCF LL-37 levels. PI,GI,PD,CAL measurements were significantly higher in both chronic periodontitis groups than controls (p<0.05). Vitamin D can act as a potent stimulater of LL-37 in DOS. Elevated levels of GCF cathelicidin LL-37 in chronic periodontitis suggest that it may play a role in the host innate immune response during periodontal inflammation.