MAKSİLLOFASİYAL BÖLGEDEKİ KEMİK İÇİ DEFEKTLERİN TEDAVİSİNDE PLATELETTEN ZENGİN PLAZMANIN DEMİNERALİZE KEMİK GREFTİ İLE BİRLİKTE KULLANIMININ ETKİNLİĞİNİN KLİNİK VE RADYOLOJİK OLARAK İNCELENMESİ

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Thesis Type: Doctorate

Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, Turkey

Approval Date: 2009

Thesis Language: Turkish

Student: M.Cenk DURMUŞLAR

Supervisor: CANSU ALPASLAN

Open Archive Collection: AVESIS Open Access Collection

Abstract:

8.SUMMARY The aim of this study is to evaluate the effects of combined use of Platelet Rich Plasma and Demineralised Bone Matrix on healing of third molar extraction sockets clinically and radiologically . 18 patients (12 women and 6 men) participated in the study. After surgical removal of bilateral impacted third molars, right site was grafted with a combination of PRP and DBM while the left side was grafted with DBM alone and served as control. İn order to measure the density of newly formed bone tissue and to evaluate the healing process, digital panoromic radiographies were taken postoperatively on the first, third and sixth months. The radiographs were examined via histogram technique on Adobe Photoshop CS2 program. Probing depths at the distal aspect of mandibular second molar teeth were also measured 1, 3 and 6 months postoperatively and evaluated for changes in clinical periodontal attachment levels. The results of the study revealed that both groups have shown similar bone healing patterns and there was no significant differance in bone densities on radiographs. A significant decrease of probing depths in both groups was recorded. In this study, it is confirmed that computer-based analysis of digital panoromic radiographs is an easy, non-invasive and cost-effective method for following the healing of bone graft substitutes. But it should be 110 kept in mind that the effects of PRP and growth factors is a relatively new research area, and many factors like the ideal bone graft substitute to combine PRP or the possible time of effect for PRP still remain unclear. Therefore, more clinical studies on this field is required.