Risk factors , clinical features and prognosis evaluation in patients with sinus vein thrombosis


Thesis Type: Expertise In Medicine

Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey

Approval Date: 2015

Student: HAVVA MELTEM MUTLUCAN

Supervisor: HALE ZEYNEP BATUR ÇAĞLAYAN

Abstract:

Cerebral venous thrombosis (CVT) one of the rare subtype of cerebrovascular diseases characterized with brain edema and increased intracranial pressure that gradually occurs via partially or totally occlusion of cerebral veins. CVT effects especially younger ages and female/male ratio is 3/1. In this study, etiological risk factors, laboratory findings, treatment options and clinical prognosis at clinical follow-up and discharge period of 53 patients whom are diagnosed with CVT on January 2006 to July 2015, retrospectively investigated. Risk factors of our study were respectively, trombophilia, hemogram abnormalities, malignities, puerperium, local infections and oral contraceptive use. In female patients, anemia with 25.8% ratio and in male patients local infections with 22.7% ratio are the most frequent risk factors. The most common symptom is headache with 69.8% and the co-occurance of more than one symptom 64.2% of all patients. The most common localization in CVT is transvers sinus. With control magnetic resonance venography images recanalization after discharge period occurs in 58.4% of all patients. The prognosis of our study appears to be better than in literature. This situation is caused by various factors. Retrospectively researching, data lose via changing of hospital database, single-center study and a limited number of patients in group might have effected the statistics. Moreover this difference might have occured because of centrals of Asian Continental were not included in ISCVT study. Over the years mortality and morbidity of CVT decreased since medical innovations. CVT is generally a multifactorial disease. Major risk factors in adult population are hypercoagulabilty, oral contraceptive use, puerperium, pregnancy, malignancies, infections, head traumas and mechanic predisposition factors. All patients who are diagnosed with CVT should have been searched for all risk factors. Overlooked factors especially sex specific ones are important for reccurences CVT attacks. Multicentral and randomized control studies are needed for comparing efficiency and reliability of treatment modalities.