Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi University, Tıp Fakültesi, Turkey
Approval Date: 2008
Thesis Language: Turkish
Student: TOLGA BAGLAN
Supervisor: ÖZLEM ERDEM
Abstract:Gleason Grading System has been the most significant prognostic factor of prostatic carsinoma for over forty years. The Gleason grading system, which has not changed in years with only a few modifications in pathology. In this study, gleason grading system, as well as other prognostics factors and two adhesion molecules E-cadherin and Beta-catenin expressions were investigated in cases with radical prostatektomy in Gazi University, Faculty of Medicine faculty between 2003 and 2008. E-cadherin and Beta-catenin expressions, evaluated by immunhistochemistry with tissue microarray analyses, were significantly decreased in cases with high gleason grading scores. In addition; expression of adhesions molecules were reduced in cases with invasion of seminal vesicule and outside the prostate. All these findings were consistent with recent literature, and indicate that decreased expression of E-cadherin and Beta-catenin may play a role in progression of prostatic carsinoma. It has been showed in this study that the prognostic factors like capsuler invasion, invasion to seminal vesicule, invasion outside the prostate, perineural invasion and tumor size were correlated with high Gleason grading system scores. Finally; we found that there was a considerable relationship between adhesion molecules, other prognostic factors and Gleason Grading System.