Research Information System
Thesis Type: Doctorate
Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2014
Student: MERVE ÇAKIR
Supervisor: İNCİ RANA KARACA
Abstract:Reconstructing edentulous maxilla with dental implants is difficult due to some complicated factors. Maxillary sinus augmentation has frequently been proposed as the best treatment option for attaining sufficient bone height and volume for implant placement in posterior maxilla. The aim of the present study was histologic and biochemical evaluation of the effect of the collagenated heterologous bone graft and Ankaferd Blood Stopper (ABS) on bone healing. In this study 36 New Zealand rabbits were used. Bilateral sinus lift was performed and 72 bone defects were obtained. The rabbit maxillary sinuses divided into 4 groups according to augmentation biomaterials: blood clot, collagenated heterologous bone graft, ABS and ABS+collagenated heterologous bone graft groups. The rabbits were sacrificed at 1, 4 and 8 weeks after surgery. Histochemical, immunohistochemical and biochemical examinations were performed on all samples. According to the histochemical and immunohistochemical examinations; lymphocyte infiltration was high at 1st week in all groups and declined from 1 to 8 weeks. All materials were biocompatible. Osteoclast number increased in control group from 1 to 8 weeks, and decreased in other groups. Bone graft particules were degenerated when used with ABS at 8th week. There was no new bone formation at the 1st week in all groups, new bone formation increased in all groups from 1 to 8 weeks. In rabbits without ABS, serum ALP levels increased from 1 to 8 weeks, in rabbits with ABS serum ALP levels increased 1 to 4 weeks and decreased from 4 to 8 weeks