OCTET STABILIZIED 1,3-DIPOLAR CYCLOADDITION REACTIONS

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Thesis Type: Doctorate

Institution Of The Thesis: Gazi Üniversitesi, Fen Bilimleri Enstitüsü, Turkey

Approval Date: 2008

Student: HAMDİ ÖZKAN

Supervisor: YILMAZ YILDIRIR

Abstract:

In this study, some novel nitrones were synthesized and their structures were determined by the use of spectroscopic methods. Then 1,3-dipolar cycloaddition reactions of synthesized nitrones with N-methyl maleimide and N-phenyl maleimide were investigated. After these reactions, some novel isoxazolidine derivatives were synthesized, then the structures of the compounds were performed by FTIR, 1H-NMR, 13C-NMR , X-Ray and LC-MS spectroscopic methods. Many isoxazolidine derivatives show antimicrobial and antifungal effects also they can be used as antibiotics. The precense of nitrogen atom in isoxazolidine ring plays an important rule in many alkaloids and releated natural product synthesis. Isoxazolidine type nucleotides such as uracil, thymine, cytosine have shown potential anti-HIV drug property. The investigations of isoxazolidine derivatives have highly importance due to these proporties.