Research Information System
Thesis Type: Doctorate
Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, FİZYOTERAPİ VE REHABİLİTASYON ANABİLİM DALI, Turkey
Approval Date: 2020
Thesis Language: Turkish
Student: UĞUR SÖZLÜ
Supervisor: Selda Başar
Abstract:
The aim of this study was to investigate the effects of neurodynamic mobilization (NM) technique on muscle damage and inflammation biomarkers, and pain, pressure pain threshold, range of motion (ROM), muscle strength, and functional status in delayed onset muscle soreness (DOMS). In the study, 32 healthy sedentary male volunteers were randomly divided into two groups as NM (n = 16) and placebo-NM (n = 16). After the initial evaluation of the individuals, femoral nerve NM and placebo NM techniques were administered three sets a day with ten repetitions for three days a week for three weeks. Three days after the end of the applications, the second evaluations were made and the DOMS creation protocol for the quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30 sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed) were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72. During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, aspartate aminotransferase (AST), and alanine aminotransferase) and inflammation (interleukin-6 (IL-6), interleukin-10, interleukin-1 beta, tumor necrosis factor-alpha, and C reactive protein) biomarkers, pain (rest and activity), pressure pain threshold, ROM, muscle strength (QF, hamstring eccentric/concentric) and performance (one-leg jump, vertical jump) parameters were measured. In the interaction of time by the group (group * time), in IL-6 level (η²: 0.162), activity pain intensity (η²: 0.165-0.110), pressure pain thresholds (η²: 0.219-0.162), active knee flexion NEH (η²: 0.097), and one leg forward jump distance (η²: 0.156), statistically significant differences were detected with varying effect size levels (p <0.05). No statistically significant difference was found between all muscle damage and inflammatory biomarkers (other than IL-6) and the severity of resting pain, passive knee flexion and active/passive knee hyperextension, ROM, all muscle strength values, and vertical jump height (p> 0.05). Individuals in the NM group had higher recovery rates at serum CC, LDH, myoglobin, AST, IL-6, IL-10, IL1-β, TNF-α, pain intensity, and QF eccentric muscle strength levels. Based on these results, it is considered that the NM technique can be applied as a preventive treatment method in reducing and controlling the symptoms caused by DOMS.
Key Words
: Delayed onset muscle soreness, Neurodynamic mobilization, Muscle damage, Inflammation, Pain