Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2011
Student: SEMA KURNAZ
Supervisor: SUNA ÖMEROĞLU
Abstract:Firstly after the interstitial cells of Cajal was explored in gastrointestinal system as pacemaker cells, the studies about Cajal cells in genital system had started. However, nowadays, the studies are not enough to explore the functions and the response of the Cajal cells to the patologic processes in genital system, yet. We intend in this study to investigate the locations, forms and other characteristics of the special pacemaker cells called Interstitial Cajal-like cells that are thought to be responsible for peristaltic activity in human uterus and tuba uterina which have extreme roles in reproductive process. In these study, various histochemical staining methods and immunohistochemistrical evaluations were accomplished to monitorize of Cajal cells in tissue materials which are excised from different anatomic regions of the human uterus tuba uterina. The human uterus is an extremely important organ, being supplied in expulsing of menstrual debris, transporting of sperm cells to the ampullary region of tuba uterina, sustaining the life of implanted zygote until birth and realization of labor by the peristaltic movements. The human tuba uterina is also an incredible organ, being supplied in guiding the sperm cells from the uterus to the ampular region, and the fertilized ovum (zigot) from the ampular region to the uterus by the agency of its peristaltic activity. Here, the conducing thing that actualize of these processes is İnterstitial Cajal-like cells. These cells are responsible for initiating and dispersing the peristalsis (slow wave electric activity). Determination of the existence and effects of the İnterstitial Cajal-like cells in human uterus and tuba uterina will enable us better understanding neurophsyology of the reproductive system.