Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi University, Sağlık Bilimleri Enstitüsü, BİYOKİMYA (ECZ) ANABİLİM DALI, Turkey
Approval Date: 2019
Thesis Language: Turkish
Student: SÜMEYYE TAMER
Supervisor: Aymelek Gönenç
Abstract:
Thyroid dysfunction is known to play a role in the pathogenesis of many diseases and is
associated with increased cardiovascular disease and mortality. Since subclinical thyroid
diseases constitute the first stage of clinical thyroid diseases, it is important to investigate
the underlying mechanisms of these diseases. Clinical investigations have revealed
changes in some adipokine levels associated with thyroid disorders. Chemerin and vaspin
are new adipokines and their relationship with thyroid hormones is not clear. It is
controversial how serum oxidized LDL, total antioxidant capacity, IL-10 levels and ABI
values change in subclinical thyroid diseases. Serum chemerin, vaspin, IL-10, oxidized LDL,
TAC levels and ABI were measured in patients who were admitted between October 2017
and August 2018 to the Endocrinology and Metabolism Unit of Gazi University Medical
Faculty Hospital, who were diagnosed with 38 subclinical hyperthyroidism and 31
subclinical hypothyroidism but were not started treatment and 44 healthy controls. Serum
chemerin levels were significantly higher in patients with subclinical hypothyroidism
compared to healthy controls and patients with subclinical hyperthyroidism. Chemerin and
vaspin levels of subclinical hyperthyroid patients were significantly lower than the control
group. Serum vaspin levels were significantly lower in patients with subclinical
hypothyroidism and subclinical hyperthyroidism than in the control group. IL-10 levels,
which are atherosclerosis-related parameters, were significantly lower in subclinical
hyperthyroid patients compared to the control group; TAC levels were higher in patients
with subclinical hypothyroidism than in the control group. There was no significant difference
between the groups in terms of oxidized LDL levels and ABI. As a result, serum chemerin
levels decreased in subclinical hyperthyroidism, serum vaspin levels decreased in
subclinical hyperthyroidism and subclinical hyperthyroidism. In terms of atherosclerotic
parameters, antioxidant defense increased in subclinical hypothyroidism, whereas IL-10,
which is antiinflammatory, decreased in subclinical hyperthyroidism. In the light of more
comprehensive studies, we think that the new adipokines chemerin and vaspine may be
candidates for biomarkers in subclinical thyroid diseases.
Key Words : c h emerin, vaspin, subclinical thyroid diseases, atherosclerosis