Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2015
Student: FATMA ASLIHAN DUMLU
Supervisor: MEHMET ANIL ONAN
Abstract:Endometrial cancer is the most common malignancy of the female reproductive system in developed countries and the fourth most common cancer in women following breast, lung and colorectal cancers. The treatment begins with surgical staging for patients with a positive endometrial sampling result. During surgery the most crucial step is the opening of the uterin specimen in the operating room and gross examination of the deepest myometrial invasion. Intraoperative frozen section is used to assist or as an alternative to the gross examination. However controversial results have been reported in studies that evaluate the consistency of the frozen section and its comparison to the final pathologic resuls. In this study, it is our purpose to compare the preoperative, intraoperative and postoperative results of endometrial cancer patients and evaluate the results for consistency. Data of patients who underwent an hysterectomy and had a pathology result of endometrial cancer between January 2010 and April 2015 in Gazi University School of Medicine, Department of Obstetrics and Gynecology were obtained from ENLIL® hospital information management system. 134 patients who also had an endometrial sampling procedure in our clinic were included. Preoperative endometrial sampling and intraoperative frozen section results were compared to the final pathology results. Endometrial sampling results were 76,1%consistent with the final results for histopathologic diagnosis and 66%for histologic grade. Frozen section results were 68,5%consistent for histopathologic diagnosis, 61,9%for depth of myometrial invasion and 93%for servical involvement. In light of this recent information, it is apparent that frozen section is inefficient and unreliable in predicting the surgical stage of endometrial cancer. Therefore we suggest standard surgical staging including lymph node dissection for patients with endometrial cancer, unless the patient has any comorbidities that would make the complete staging impossible.