Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2018
Thesis Language: Turkish
Student: BİRSEN ÖZTÜRK GÖKÇE
Supervisor: MÜJDE YAŞIM AKTÜRK
Abstract:The aims of our study were to investigatelower extremity tendons, soft tissue, muscle groups in terms of thickness, pennation angle, and the presence of enthesitis,to evaluate the levels of myostatin, Procollagen III N-Terminal Peptide (PIIINP) and quality of life, fatigue in acromegaly patients. Thirty-nine acromegaly patients and 39healthy control subjects similar for age, sex and body mass index were enrolled. Lower extremity tendon, skin, and muscles were evaluated by ultrasound. Acroqol and MAF questionnaires were applied. The thickness of Achilles tendon, skin, plantar fascia and heel were higher in acromegaly group than the control group (p <0.05).The incidence of Achilles and patellar enthesitis were increased in the acromegaly group (p<0.05). The thickness of the gastrocnemius medial head, vastus medialis,lateralis muscles for both sides andthe left rectus femoris muscle were found to be lower in the acromegaly patients (p<0.05). PA values of the right and left vastus medialis and the right vastus lateralis were found to be decreased in the acromegaly group (p<0.05). Myostatin levels were lower in acromegaly group, and PIIINP levels were similar between the groups (p <0.05, p> 0.05). MAF score was higher in active and inactive acromegaly patients group than in control groups (p<0,05).In conclusion; acromegaly may cause to an increase in soft tissue and tendon thicknesses, enthesitis formation, decrease in the thickness of some muscles, and deterioration in microstructures (indicating decreased muscle strength). These changes may contribute to an impairment in the quality of life and an increase in fatigue in acromegaly