Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2019
Thesis Language: Turkish
Student: OSMAN SÜTCÜOĞLU
Supervisor: MELDA TÜRKOĞLU
Abstract:Nowadays, there has been an increase in the need for intensive care as a result of prolonged survival and increased chronic / acute diseases. As a result of this increasing need, medical developments in the intensive care unit are accelerated and the reduction of intensive care unit mortality is the main target. Various scoring systems, markers are used in intensive care practice, and molecules that can predict mortality and change the course of treatment continue to be investigated. The ideal marker should be cheap, easy to use in daily practice. Looking at the serum uric acid level seems to be useful in predicting intensive care mortality due to meeting these criteria and reflecting the antioxidant capacity in plasma. For this purpose; The serum uric acid levels of 510 patients admitted to the Internal Medicine Intensive Care Unit between August 2016 and August 2018 were investigated and the relationship between uric acid level and intensive care mortality was tried to be demonstrated. The aim of the study was to investigate the relationship between the underlying diseases of the patients, the diagnosis of intensive care hospitalization, the duration of hospitalization and uric acid. In our study, the normal serum uric acid level was determined to be 3-7 mg / dl, independent of age and sex, and low or high uric acid level was found to increase intensive care mortality. The APACHE-II score used in current intensive care follow-up was correlated with serum uric acid level. It was determined that vii urinary acid level 7.05 had 51% sensitivity and 72% specificity in predicting mortality. In the light of these findings, the predictive effect of serum uric acid level and intensive care mortality rate was determined statistically. It seems reasonable to integrate serum uric acid levels into intensive care scoring systems. Additional studies are needed to determine the effect of uric acid level on daily mortality and the contribution of uric acid level at the time of admission to predicting 30 and 90 days mortality.