Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2013
Student: HATİCE ŞEN
Supervisor: HÜSEYİN BORA
Abstract:SUMMARY Definition of the Pelvic Structure in Computerized Tomograpy and Magnetic Resonanse Imaging by Using Image Fusion in Radiotherapy Planning for Prostate Cancer Prostate cancer is the sixth common malignancy in Turkey. The main treatment choices for men with clinically localized prostate cancer are radical prostatectomy, external beam radiotherapy. Radiotherapy and prostatectomy are curatively treatments and have high local control ratio. High-precision three dimensional conformal radiation therapy (3D-RT) using sophisticated computer-aided treatment planning, along with surgery, has been accepted as standard therapy for localized prostate cancer. High dose conformal radiotherapy for prostate cancer increases local control. The success of dose escalation depends on correct staging and target volume identification. Prostate is surrounded by several soft-tissue. Magnetic resonance imaging (MRI) has better soft-tissue resolution, and shows the interfaces more clearly. Fifteen consecutive patients with clinically localized prostate cancer were prospectively evaluated with CT-MR fusion images. Our study was to assess the advantage of CT?MRI image fusion and differenses for volume delination. Each patient underwent CT in the treatment position. MR imaging was also performed in the treatment position after to the CT. Both images automatically matched in three dimensions. One radiation oncologist contoured the prostate, SV, rectum, PB of all the patients referring to all the CT and MR images. They checked by experienced radiologist. The mean delineated volumes of the prostate SV, rectum, PB analyzed. We found statistically significant difference between SV values. We showed that MRI yields more contrast than CT when differentiating the prostate (apex, basis), rectum, PB. Prostate-Rectum and apex- PB distance identified clearly by MRI. Finally; MRI compere with CT appears to provide improved definition of pelcic treatment volumes for prostate radiotherapy.