Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2015
Student: AYTEN İPEK
Supervisor: ESRA AKKOL
Abstract:Species of Polygala have been used against inflamation and pain in Turkish traditional medicine as well as all around the world. The decoction of the aerial parts of P. anatolica Boiss. et Heldr is used against inflammation in Afyon, Kütahya, Denizli, Muğla ve Aydın and as expectorant, diuretic and galactagog and for the purpose of perspiration in Uşak province. The aim of the present study is to assess the anti-inflammatory and analgesic activities of P. anatolica by using different in vivo models through bioassay-guided fractionation techniques (BAGF) to determine its active ingredients. n-Hexane, ethylacetate and ethanol extracts of the aerial parts and roots of P. anatolica, one of the most common species in Turkey, were investigated for its anti-inflammatory effect. The ethanol extract prepared from the aerial parts of P. anatolica was processed to BAGF. In order to determine the anti-inflammatory activity of these extracts and fractions, different models of oedema such as PGE2- and carrageenan-induced hind paw oedema and Whittle method were used. For determination of the analgesic activity p-benzoquinone-induced pain test was applied. The ethanol extract obtained from the aerial part of the plant and its saponoside and flavonoid fractions showed anti-inflammatory activity in the trials