Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Fen Bilimleri Enstitüsü, Turkey
Approval Date: 2017
Student: ESRA BAKAN
Supervisor: ÜMMÜHAN ÖZDEMİR ÖZMEN
Open Archive Collection: AVESIS Open Access Collection
Abstract:This work was designed to have two phases. In the first phase of the thesis, thiazole-coumarin hybrid systems containing different pharmacological properties and Schiff bases formed by their bindings with various aldehydes were synthesized. The synthesized Schiff bases are 4-diethylaminosalicylaldehyde thiazole coumarin(L1), 4-methoxysalicylaldehyde thiazole coumarin (L2) and 3,5-ditertiarybutylsalicylaldehyde thiazole coumarin(L3). The structures of new coumarin thiazole Schiff bases have been characterized by spectroscopic methods ( FTIR, 1H/13C-NMR, LC/MS). Sensitivity studies of the synthesized Schiff Bases have been determined against different anion (F-, Cl-, Br-, I-, AcO-, CN-, H2PO4-, HSO4-and NO3- ) and cemosensor properties have been examined. All of Schiff bases have interacted with added F- , AcO- and CN- . In the second phase of the thesis, the complexes of coumarin thiazole Schiff bases with Pd(II), Pt(II) metals have been synthesized . The complexes of coumarin thiazole Schiff bases have general formulae as ML2, (M=Pd(II), Pt(II)) and their structures have been determined by using FT-IR, LC/MS, UV-GB spectra, magnetic susceptibiliy and molar conductivity methods. In addition, anti-cancer activity of all the synthesized compounds have been evaluated in vitro mode using MTT assay on the human cancer cell lines human breast adenocarcinoma, MCF-7 and human prostate adeno carcinoma, DU145). According to the anti-cancer activity results, most of the compounds have shown better anti-cancer activities on human breast adenocarcinoma, MCF-7 cancer cell lines.