Research Information System
Thesis Type: Doctorate
Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 2017
Student: NESLİHAN COŞKUN AKÇAY
Supervisor: SUNA ÖMEROĞLU
Abstract:It is known that formation and progression of Metabolic Syndrome (MetS), the modern city life in the contributes to the sedentary lifestyle, increased obesity due to high calorie diet, physical inactivity, stress, genetic factors and environmental factors. MetS causes abnormal adipose tissue function, hepatic steatosis, heart disease, abnormal gastrointestinal activity, systemic inflammation, the release of pancreatic hormones, the activity of gastric hormones, chronic complications of diabetes which affects many physiological and biochemical processes, such as male and female reproductive function disorders. Studies have shown that BPA, which is an environmental endocrine disruptor, and fructose, which causes liver steatosis that frequently confronts the daily diet, contributes to the formation of MetS by causing increased free radical formation, glucose autooxidation, protein glycation and alteration of antioxidant defense systems. For these purpose, fourty-two pubertal male Sprague Dawley rats were divided equally into seven groups. Groups are designed; Group 1:(n=6) Control, Group 2: (n=6) Fructose Group, Group 3: (n=6) BPA Group, Group 4: (n=6) Fructose+BPA Group, Group 5: (n=6) Fructose+Melatonin Group, Group 6: (n=6) BPA+Melatonin Group, Group 7: (n=6) Fructose+BPA+Melatonin Group. At the end of the experimental period, received the blood samples and liver tissue, in light of these information and consistent with the literature, we investigated any variations in the liver tissue and adipocytokines when exposed to BPA and Fructose and to determine the possible effects of melatonin exposure against the variations which may occur. While, BPA, Fructose and the simultaneous application of both cause liver damage, whereas melatonin application was found to be successful in preventing this damage.