Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2015
Student: MERVE ÖZTÜRK
Supervisor: MESUT ÖKTEM
Abstract:Polycystic ovary syndrome (PCOS) is multifactorial and systemic disease and very common in reproductive age women. Patients with PCOShave high risk for metabolic syndrome and cardiovascular disease. PAPP-A, a member of IGF axis, plays a role in atherosclerosis, acute coronary syndrome and other cardiac disease like diabetes mellitus. The aim of this study is to evaluate serum concentrations of PAPP-A in relationship with cardiovascular disease risk prediction in patients with PCOS. This study is was consisted 64 patients with PCOS and 66 patient in control group, totally 130 patient between 18-45 aged. Study was designed prospectively. 64 patients with PCOS and 66 body mass index matched controls were divided into two groups, based on BMI: BMI<27kg/m2and BMI≥27 kg/m2 .Hormonal and metabolic profile as well as PAPP-A levels evaluated in each group. In BMI<27kg/m2 group, PAPP-A levels was significantly higher in women with PCOS group compared to age-matched control group (1,8 (1,1-3,0) ng/ml versus 2,1 (1,1-3,0) ng/ml p=0.018). Also in PCOS group PAPP-A levels was higherin women whose BMI<27kg/ m2 than BMI≥27 kg/m2 (2,1 (1,1-4,1) ng/ml versus 1,5 (0,7-3,3) ng/ml p=0,002). But there was no significant elevation of serum PAPP-A levels in women with entire PCOS compared to controls group (1,7 (0,8-3,1)ng/ml vs 1,8 (0,7-4,1) ng/ml p=0,328) PAPP-A levels correlated significantly negatively with BMI (r=-0,265 ve p=0,002), age (r=-0,189 and p=0,031) and triglyceride levels(r=-0,300 ve p<0,001). As it is believed that PAPP-A was released in early phase of plaque rupture in coronary syndrome (CS), PAPP-A is considered as an early marker of diagnose of acute CS. Furthermore, PAPP-A levels can be used as a clinic indicator in young patients with PCOS whose BMI<27kg/ m2 to predict cardiovasculary disease risk. This study has importance as it is the first study in the literature that evaluated PAPP-A levels in women with PCOS.