Research Information System
Thesis Type: Expertise In Medicine
Institution Of The Thesis: Gazi Üniversitesi, Tıp Fakültesi, Turkey
Approval Date: 2017
Student: ÖZGE MİNE ÖRENAY
Supervisor: AYLA GÜLEKON
Abstract:Acne vulgaris (AV) is a multifactorial, chronic inflammatory disease of the pilosebaceous unit. There are four main factor in acne pathogenesis which are overproduction of sebum secretion, follicular hyperkeratosis, propionibacterium acnes (P. acnes) colonization and inflammation. In our study, comparison of perilipin 2 (PLIN2) and melanocortin 5 receptor (MC5-R) levels, effective in sebogenesis, is intended. 65 patients, aged 15-25, with AV diagnosis and 46 healthy volunteer were included in this study. Body mass index, lipid profile, PLIN2, MC5-R and meal frequency of the participants were examined. In our study, there was no statistical significant difference between the patient group and control group in terms of body mass index, lipid profile, PLIN2 and MC5-R levels. PLIN2 and MC5-R levels in moderate acne group is statistically higher compare to mild acne groups. However, same correlation was not determined between severe acne group compare to mild and moderate acne group. These findings suggest that PLIN2 and MC5-R levels may play a part in acne severity rather than acne pathogenesis. On the other hand, the fact that same increase was not detected between severe acne group and other groups suggests that PLIN2 and MC5-R levels affect acne severity to a certain extent. As a result, further studies are needed to clarify the association between acne and PLIN2 and MC5-R levels.