Evaluatıon Of Cranıofacıal Morphology In Patıents Wıth Chronıc Kıdney Dısease

Thesis Type: Doctorate

Institution Of The Thesis: Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Turkey

Approval Date: 2014




The aim of this study was to evaluate the effect of chronic kidney disease (CKD) which impairs mineral and bone metabolism and causes growth retardation, on craniofacial morphology by cephalometric analysis, in patients who were diagnosed during growth and development period. 31 patients with CKD included in this study. Patients with CKD divided into 2 subgroups according to the severity of the disease as pre-dialysis and dialysis. Pre-dialysis group consisted of 13 subjects (6 female, 7 male) whose chronological ages ranged from 9.75 to 18.5 years (mean age 15.05±2.91 years) and dialysis group consisted of 18 subjects (7 female, 11 male) whose chronological ages ranged from 7 to 21 years (mean age 14.75±3.76 years). Control group consisted of pre-treatment materials of age and gender matched 31 healthy subjects with skeletal class 1 relationship without any medical disorder chosen from Gazi University Faculty of Dentistry Department of Orthodontics Archive. Lateral cephalometric, panoramic, hand and wrist radiographs were collected to evaluate craniofacial morphology, dental health status and bone age of the subjects. The data was analysed with parametric and non-parametric tests with a significance level of p<0.05. The results showed CKD patients in both groups have significantly reduced anterior and posterior cranial base lengths, larger cranial base and middle cranial base angles, decreased posterior cranial base angle, reduced maxillary base length, increased gonial angle, decreased posterior facial height, increased maxillary/mandibular plane angle and increased mandibular posterior rotation. CKD patients in dialysis group also showed significant decreases in ramus height, mandibular base length and upper anterior face. We concluded that, patients with CKD who were diagnosed during growth and development period exhibit significant morphological changes in craniofacial features compared to the healthy subjects.