Research Information System
Thesis Type: Postgraduate
Institution Of The Thesis: Gazi Üniversitesi, Fen Bilimleri Enstitüsü, Turkey
Approval Date: 2015
Student: İMRAN SENA SİTEMOĞLU
Supervisor: YUSUF KALENDER
Open Archive Collection: AVESIS Open Access Collection
Abstract:Mercury and lead, which are the most important environmental and industrial contaminants, adversely affects human health. In this study, mercuric chloride (0.02 mg/ kg day), lead nitrate (45 mg/kg day) and lead nitrate+mercury chloride (45 mg / kg day lead nitrate + 0,02 mg/kg day mercury chloride) were given to male rats through gavage. 4 weeks after treatment were examined histopathological changes that occur in the small intestine in rats with a light microscope and was examined in comparison with the control group. 28-day implementation period when intestinal tissue taken in examination results in the group treated with mercuric chloride in an intensive and villous atrophi necrosis has been observed. In the group treated with lead nitrate, necrosis and inflammatory changes have been observed. In the group treated with mercuric chloride+lead nitrate, necrosis in the mucosal epithelium, degeneration of the villi and loss villus epithelium was determined. As a result lead nitrate and mercury chloride caused more toxic effects than other groups.