Akademik Veri Yönetim Sistemi
Sağdıçoğlu Celep A. G. (Yürütücü), Kondolot Solak E., Demirkaya A.
Yükseköğretim Kurumları Destekli Proje, 2017 - 2018
Polyphenols are compounds that contain more than one phenol group per molecule and are found in several foods. Polyphenols are of great interest due to their beneficial effects against many diseases such as cancer. In addition, polyphenols are of great importance for health due to their high antioxidant properties. Gallic acid (GA), which is a powerful antioxidant, has anticancer properties on various cancer cells. Microspheres are carriers varying in size from 1- trapped in polymer matrix. Controlled release profile is aimed at target region by preserving loss of substance and activity until active substance reaches target region. In this study, GA containing microspheres were formed with NaAlg which is a natural polymer in formulations with GA/NaAlg ratio of 1/1-1/8 by usingwater/oil /water emulsion method, and CaCl2 was used as a crosslinker. Microsphere yields of obtained microspheres were 15,55-80,27%; arrest efficiencies ranged from 11,26-72,64%. Release studies of microspheres were performed at pH 7.4. Optimum microsphere forming conditions were determined as GA/NaAlg ratio 1/8, crosslinking time 30 min. Microspheres formed were found to arrest GA and exhibit a controlled release profile. Microspheres were characterized by SEM, DSC, XRD, FTIR analysis. It was demonstrated by DPPH method that GA retained antioxidant activity in microspheres and that retain anticancer activity by using MTT analysis on Caco-2 cells. It is considered that important to carry out other necessary studies on GA loaded NaAlg microspheres which have high potential to be used in adjunct and complementary therapies.