Comparison Pharmacokinetic Dosing Tools in Hemophilia A Children


Genc C. A., Gokcebay D. G., Culha V. K., KAYA Z., Ozbek N. Y.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, vol.40, no.1, pp.108-115, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1007/s12288-023-01671-0
  • Journal Name: INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE
  • Page Numbers: pp.108-115
  • Keywords: Clearance, Dosing tool, Factor VIII, Half-life, Hemophilia A, Pharmacokinetics
  • Gazi University Affiliated: Yes

Abstract

Prophylaxis is the gold standard for the management of hemophilia A patients. It has been shown that prophylaxis regulated with pharmacokinetic (PK) data reduces frequency of bleeding and cost of treatment. To determine the best prophylaxis regimen, PK dosing tools using the Bayesian method have been developed. We aimed to compare two PK dosing tools. Blood samples were drawn before, 4, 24, and 48 h after FVIII infusions from patients with severe hemophilia A and inhibitor negative. FVIII levels were measured by PTT-based one-stage assay method. PK parameters obtained using WAPPS and myPKFiT, which are web-accessible PK dosing tools using Bayesian algorithm, and daily prophylaxis dose estimated by the programs were compared. Forty-two hemophilia A patients [median age 13 years (IQR 8.9-16.4)] included in the study. There was no difference between the daily dose of FVIII given for prophylaxis and the dose recommended by the myPKFiT for the 1% trough level; whereas, a significant difference was found with the WAPPS. The half-lives of FVIII did not differ between the two dosing tools; however, significant differences were found in the estimated dose, clearances, and times to 1% trough level. There was no significant difference between PK data of patients who received Advate (R) and those who received non-Advate (R) factor concentrates. Choice of PK dosing tool can affect recommended FVIII dose. However, target trough levels should be individualized according to bleeding phenotype and daily activity of patient.