Acute Megakaryoblastic Leukemia with t(1;22) Mimicking Neuroblastoma in an Infant

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Gokce M., AYTAÇ EYÜPOĞLU Ş. S., ÜNAL S., Altan İ., GÜMRÜK F., Cetin M.

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.1, pp.64-67, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2013.0189
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.64-67
  • Gazi University Affiliated: No

Abstract

Acute megakaryoblastic leukemia (AMKL) with t(1;22) (p13;q13) is an extremely rare subtype of acute myeloid leukemia that is almost always described in infants. t(1;22) (p13;q13)-positive AMKL with extramedullary infiltration has been previously reported only once in the literature. Herein, we report a 3-month-old infant presenting with a pelvic mass and pancytopenia suggesting neuroblastoma. Bone marrow evaluation revealed t(1;22)-positive AMKL that responded well to a regimen containing high-dose cytarabine.