Protective effect of vitamin A on ARA-C induced intestinal damage in mice

Elli, Murat; Aydin, Oguz; Bilge, Sirri; Bozkurt, Ayhan; Dagdemir, Ayhan; PINARLI, FARUK; Acar, Sabri

doi:10.1177/030089160909500114

Protective effect of vitamin A on ARA-C induced intestinal damage in mice

Elli M., Aydin O., Bilge S., Bozkurt A., Dagdemir A., PINARLI F. G., ...More

TUMORI J, vol.95, no.1, pp.87-90, 2009 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 95 Issue: 1
Publication Date: 2009
Doi Number: 10.1177/030089160909500114
Journal Name: TUMORI J
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.87-90
Keywords: cytarabine, mucosal damage, protection, mice, vitamin A, DEFICIENCY, TOXICITY, LEUKEMIA, ACIDS
Gazi University Affiliated: Yes

Abstract

Background. Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to investigate whether vitamin A (VA) can help prevent ARA-C-induced mucosal lesions in mice.