Protective effect of vitamin A on ARA-C induced intestinal damage in mice

Elli, Murat; Aydin, Oguz; Bilge, Sirri; Bozkurt, Ayhan; Dagdemir, Ayhan; PINARLI, FARUK; Acar, Sabri

doi:10.1177/030089160909500114

Protective effect of vitamin A on ARA-C induced intestinal damage in mice

Elli M., Aydin O., Bilge S., Bozkurt A., Dagdemir A., PINARLI F. G., ...Daha Fazla

TUMORI J, cilt.95, sa.1, ss.87-90, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 95 Sayı: 1
Basım Tarihi: 2009
Doi Numarası: 10.1177/030089160909500114
Dergi Adı: TUMORI J
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.87-90
Anahtar Kelimeler: cytarabine, mucosal damage, protection, mice, vitamin A, DEFICIENCY, TOXICITY, LEUKEMIA, ACIDS
Gazi Üniversitesi Adresli: Evet

Özet

Background. Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to investigate whether vitamin A (VA) can help prevent ARA-C-induced mucosal lesions in mice.