Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

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Kaltalioglu K., COŞKUN CEVHER Ş.

RENAL FAILURE, vol.38, no.8, pp.1291-1299, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1080/0886022x.2016.1209383
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1291-1299
  • Keywords: Cisplatin, hesperidin, morin, nephrotoxicity, oxidative stress, NITRIC-OXIDE PRODUCTION, OXIDATIVE STRESS, MECHANISMS, ANTIOXIDANT, DAMAGE, CELLS, PHARMACOLOGY, GLUTATHIONE, INHIBITION, HYDRATE
  • Gazi University Affiliated: Yes

Abstract

Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into seven groups: control, morin, hesperidin, cisplatin, cisplatin+morin, cisplatin+hesperidin, and cisplatin+morin+hesperidin. Morin and/or hesperidin were given for 10 consecutive days by oral gavage and on the 4th day a single dose of cisplatin (7mg/kg) was injected intraperitoneally. After administrations, on the 11th day of the experiment the animals were killed, and malondialdehyde (MDA), nitric oxide (NOx), glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) activity were measured. Cisplatin-treated rats showed increased levels of MDA, and decreased levels of NOx also activity of CAT. Morin and/or hesperidin pretreatment prevent oxidative stress in kidney tissue, while they increase the NOx level, CAT activity, and decrease MPO activity. In conclusion, morin+hesperidin pretreatment may have a significant potential for protection of cisplatin-induced nephrotoxicity.