Biomarker and shear stress in secondary pediatric pulmonary hypertension
TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.6, pp.1854-1860, 2017 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 6
- Publication Date: 2017
- Doi Number: 10.3906/sag-1609-13
- Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.1854-1860
- Keywords: Biomarkers, child, congenital heart defects, pulmonary hypertension, shear strength, C-REACTIVE PROTEIN, ARTERIAL-HYPERTENSION, NATRIURETIC PEPTIDE, HEART-DISEASE, CHILDREN, INFLAMMATION, CHALLENGES, ADULTS
- Gazi University Affiliated: Yes
Abstract
Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting.