Biomarker and shear stress in secondary pediatric pulmonary hypertension

PEKTAŞ A., Olgunturk R., KULA S., Cilsal E., OĞUZ A. D., TUNAOĞLU F. S.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.6, ss.1854-1860, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1609-13
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1854-1860
  • Anahtar Kelimeler: Biomarkers, child, congenital heart defects, pulmonary hypertension, shear strength, C-REACTIVE PROTEIN, ARTERIAL-HYPERTENSION, NATRIURETIC PEPTIDE, HEART-DISEASE, CHILDREN, INFLAMMATION, CHALLENGES, ADULTS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting.