Biomarker and shear stress in secondary pediatric pulmonary hypertension

PEKTAŞ A., Olgunturk R., KULA S., Cilsal E., OĞUZ A. D., TUNAOĞLU F. S.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.6, pp.1854-1860, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1609-13
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1854-1860
  • Keywords: Biomarkers, child, congenital heart defects, pulmonary hypertension, shear strength, C-REACTIVE PROTEIN, ARTERIAL-HYPERTENSION, NATRIURETIC PEPTIDE, HEART-DISEASE, CHILDREN, INFLAMMATION, CHALLENGES, ADULTS
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting.