Photodynamic Therapy-Induced Microvascular Changes in a Nonmelanoma Skin Cancer Model Assessed by Photoacoustic Microscopy and Diffuse Correlation Spectroscopy

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Rohrbach D. J., Salem H., Aksahin M. F., Sunar U.

PHOTONICS, cilt.3, sa.3, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3390/photonics3030048
  • Dergi Adı: PHOTONICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: skin cancer, microvasculature, photoacoustic microscopy, blood flow, photodynamic therapy, BASAL-CELL CARCINOMAS, BLOOD-FLOW, HEMODYNAMIC-RESPONSES, DETERMINES, US
  • Gazi Üniversitesi Adresli: Hayır

Özet

One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.