Effect of single dose alcohol administration on malondialdehyde, glutathione, total protein and hydroxyproline levels of rat liver

DİNCER S., ORHAN E., Ozenirler S.

Turkish Journal of Gastroenterology, cilt.10, sa.1, ss.1-3, 1999 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 1999
  • Dergi Adı: Turkish Journal of Gastroenterology
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-3
  • Anahtar Kelimeler: Alcohol, Glutathyone, Hydroxyproline, Liver, Malondialdehide, Total protein
  • Gazi Üniversitesi Adresli: Evet

Özet

The effect of single dose alcohol administration on the malondialdehyde, glutathione, total protein and hydroxyproline levels of rat liver was evaluated. Sixteen Wistar rats with an average weight of 150-200 g were used in the study. A single dose of 40% ethanol, 0.5 g/kg of body weight was administered intraperitoneally (i.p.) to the study group of ten rats while a control group of six rats received the same dose of 0.9% NaCl (saline). After 24 hours all the rats were killed and their liver was obtained and evaluated. A significant decrease (p<0.05) was observed only in glutathione levels after 24hrs and this decrease was not dose dependent.