Effects of Atorvastatin on Experimental Spinal Cord lschemia-Reperfusion Injury in Rabbits

Creative Commons License

Kardes O., Civi S., Tufan K., Oz Oyar E., ÖMEROĞLU S., AYKOL Ş.

TURKISH NEUROSURGERY, vol.27, no.4, pp.594-602, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.5137/1019-5149.jtn.16627-15.2
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.594-602
  • Keywords: Atorvastatin, lschemia/reperfusion injury, Statin, Spinal cord injury, NITRIC-OXIDE, LIPID-PEROXIDATION, ENDOTHELIAL DYSFUNCTION, REDUCTASE INHIBITOR, CEREBRAL-ISCHEMIA, OXIDATIVE STRESS, RATS, STATINS, CONSTRICTION, SIMVASTATIN
  • Gazi University Affiliated: Yes

Abstract

AIM: Extent of secondary injury is the determinant of tissue destruction and functional worsening after primary spinal cord injury (SCI). Data have accumulated on alleviation of secondary injury in SCI from many studies on the subject. Besides its cholesterol lowering effects, statins are known to have anti-inflammatory and anti-oxidant effects which are the main targets of spinal cord research. This study aims to evaluate the effects of atorvastatin on experimental spinal cord ischemia-reperfusion injury.