Resveratrol Supplementation Gender Independently Improves Endothelial Reactivity and Suppresses Superoxide Production in Healthy Rats

Soylemez S., SEPİCİ DİNÇEL A., AKAR F.

CARDIOVASCULAR DRUGS AND THERAPY, vol.23, no.6, pp.449-458, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1007/s10557-009-6198-z
  • Journal Name: CARDIOVASCULAR DRUGS AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.449-458
  • Keywords: Resveratrol, Endothelial reactivity, Superoxide, Angiotensin II, Health promotion, Male and female rats, SPONTANEOUSLY HYPERTENSIVE-RATS, INTERNAL MAMMARY ARTERY, NITRIC-OXIDE PRODUCTION, VASCULAR SUPEROXIDE, OXIDATIVE STRESS, FEMALE RATS, RED WINE, IN-VIVO, ESTROGEN, CELLS
  • Gazi University Affiliated: Yes

Abstract

Resveratrol, a polyphenolic compound mainly abundant in red wines, has beneficial cardiovascular effects on various pathological conditions. However, at present, the effect of resveratrol on health promotion remains unclear. Therefore, in this study, we assessed whether long-term resveratrol supplementation changes endothelial function, vascular contractility, nitric oxide and superoxide production in healthy male and female rats.