Oxcarbazepine does not suppress cortical spreading depression


Hoffmann U., Dilekoez E., Kudo C., Ayata C.

CEPHALALGIA, vol.31, no.5, pp.537-542, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1177/0333102410388433
  • Journal Name: CEPHALALGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.537-542
  • Keywords: Cortical spreading depression, migraine, oxcarbazepine, valproate, MIGRAINE PROPHYLAXIS, NEUROPATHIC PAIN, RAT, CARBAMAZEPINE, VALPROATE, DAMAGE, MODEL
  • Gazi University Affiliated: Yes

Abstract

Background: Cortical spreading depression is the electrophysiological substrate of migraine aura, and may trigger headache. Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis.