Oxcarbazepine does not suppress cortical spreading depression


Hoffmann U., Dilekoez E. , Kudo C., Ayata C.

CEPHALALGIA, vol.31, no.5, pp.537-542, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1177/0333102410388433
  • Title of Journal : CEPHALALGIA
  • Page Numbers: pp.537-542
  • Keywords: Cortical spreading depression, migraine, oxcarbazepine, valproate, MIGRAINE PROPHYLAXIS, NEUROPATHIC PAIN, RAT, CARBAMAZEPINE, VALPROATE, DAMAGE, MODEL

Abstract

Background: Cortical spreading depression is the electrophysiological substrate of migraine aura, and may trigger headache. Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis.