The effect of levosinnendan on myocardial ischemia reperfusion injury in streptozotocin-induced diabetic rats

KİRAZ H. A., Poyraz F., KİP G., ERDEM O. A., ALKAN M., ARSLAN M., ...Daha Fazla

LIBYAN JOURNAL OF MEDICINE, cilt.10, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3402/ijm.v10.29269
  • Dergi Adı: LIBYAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: ischemia-reperfusion, levosimendan, myonecrosis, inflammatory cell infiltration, diabetic rat, K-ATP CHANNELS, LEVOSIMENDAN, HEART, DEXMEDETOMIDINE, ACTIVATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Ischemia/reperfusion (I/R) injury is an important cause of myocardial damage by means of oxidative, inflammatory, and apoptotic mechanisms. The aim of the present study was to examine the potential cardio protective effects of levosimendan in a diabetic rat model of myocardial I/R injury.