Stobadine protects rat kidney against ischaemia/reperfusion injury.


Guz G., Demirogullari B., Ulusu N. N. , Dogu C., Demirtola A., Kavutcu M. , ...More

Clinical and experimental pharmacology & physiology, vol.34, no.3, pp.210-6, 2007 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1681.2007.04574.x
  • Title of Journal : Clinical and experimental pharmacology & physiology
  • Page Numbers: pp.210-6
  • Keywords: glutathione, ischaemia, kidney, malondialdehyde, reperfusion, stobadine, INDUCED DIABETIC-RATS, REPERFUSION-INDUCED INJURY, PENTOSE-PHOSPHATE PATHWAY, ACUTE-RENAL-FAILURE, LIPID-PEROXIDATION, VITAMIN-E, IN-VIVO, ANTIOXIDANT, GLUTATHIONE, ISCHEMIA

Abstract

1. Ischaemia-reperfusion (I/R) injury, one of the main causes of acute renal failure, still needs satisfactory treatment for routine clinical application. Stobadine, a novel synthetic pyridoindole anti-oxidant, has the ability to reduce tissue injury induced by mechanisms involving reactive oxygen species during I/R. The aim of the present study was to determine the effects of stobadine on renal I/R injury.