The Effects of Melatonin on Intestinal Adaptation in a Rat Model of Short Bowel Syndrome

Guclu M., Demirogullari B., BARUN S., Ozen I. O., Karakus S. C., POYRAZ A., ...More

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, vol.24, no.2, pp.150-157, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1055/s-0033-1343081
  • Journal Name: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.150-157
  • Keywords: apoptosis, intestinal adaptation, melatonin, short bowel syndrome, GASTROINTESTINAL-TRACT, PARENTERAL-NUTRITION, FUNCTIONAL-CHANGES, RESECTION, GROWTH, MECHANISMS, TRYPTOPHAN, CHILDREN, LOCALIZATION, PHYSIOLOGY
  • Gazi University Affiliated: Yes

Abstract

Introduction Short bowel syndrome (SBS) is a clinical condition resulting from the loss of absorptive surface area following resection of 50% or more small bowel. Morphological and functional changes called "intestinal adaptation" occur in the residual intestine. Melatonin exists in the gastrointestinal tract and has effect on mitotic activity. Therefore, we hypothesized that melatonin may have beneficial effects on intestinal adaptation.