Clinical outcome of magnetic activated cell sorting of non-apoptotic spermatozoa before density gradient centrifugation for assisted reproduction

Dirican, Enver; Ozgun, Osman; Akarsu, Sueleyman; Akin, Kadir; Ercan, Oezge; Ugurlu, Mukaddes; Camsari, Cagri; Kanyilmaz, Oya; Kaya, Adnan; Unsal, ALİ

doi:10.1007/s10815-008-9250-1

Clinical outcome of magnetic activated cell sorting of non-apoptotic spermatozoa before density gradient centrifugation for assisted reproduction

Atıf İçin Kopyala

Dirican E. K., Ozgun O. D., Akarsu S., Akin K. O., Ercan O., Ugurlu M., ...Daha Fazla

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.25, sa.8, ss.375-381, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25 Sayı: 8
Basım Tarihi: 2008
Doi Numarası: 10.1007/s10815-008-9250-1
Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.375-381
Anahtar Kelimeler: Apoptosis, Spermatozoa, Intracytoplasmic sperm injection, Pregnancy rate, PLASMA-MEMBRANE TRANSLOCATION, DNA FRAGMENTATION, HUMAN SPERM, ANNEXIN-V, OXIDATIVE STRESS, EJACULATED SPERM, IN-VITRO, FERTILIZATION, DAMAGE, PHOSPHATIDYLSERINE
Gazi Üniversitesi Adresli: Hayır

Özet

Purpose Magnetic activated cell sorting (MACS) eliminates apoptotic spermatozoa based on the presence of externalized phosphatidylserine residues. We evaluated the outcome of male fertility treatment when intracytoplasmic sperm injection (ICSI) into human oocytes was performed with non-apoptotic MACS-selected spermatozoa.