Profile of psychotropic agents used in autism spectrum disorder according to comorbidities in Turkey: A 4-year evaluation


Karabacak Y., Barun S., Vural İ. M., Vural E., Iseri E., Kahve A., ...Daha Fazla

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, cilt.38, sa.4, ss.216-222, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1097/yic.0000000000000456
  • Dergi Adı: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.216-222
  • Anahtar Kelimeler: autism spectrum disorder, comorbidity, pharmacoepidemiology, psychotropic pharmaceuticals, Turkey
  • Gazi Üniversitesi Adresli: Evet

Özet

It is known that the use of psychotropic pharmaceuticals is common in comorbidities seen in autism spectrum disorder (ASD). We have very limited knowledge about which psychotropic drugs are prescribed when comorbidities are diagnosed in patients with ASD. It is aimed to determine the profile of psychotropic agents in patients diagnosed with ASD associated with comorbidities between the ages of 0-24 in Turkey over 4 years. Data belonging to ASD in Prescription Information System (PIS) was obtained from the 'Turkish Medicines and Medical Devices Agency'. A total of 34 066 prescriptions including 45 624 psychotropic drugs were analyzed. A total of psychotropic drugs prescribed for patients with ASD was 75.4%. The following psychotropic drugs were prescribed for the patients with ASD and its comorbidities; risperidone (28.6%), aripiprazole (13.7%), and valproic acid (11.3%) are the most preferred psychotropics. The percentage of pharmaceuticals containing psychotropic active substances in prescriptions with ASD and its comorbidities is 7.5%. This study is the first research in which psychotropics used in ASD were evaluated over a wide period and nationwide. Antipsychotics were most commonly prescribed with the diagnosis of ASD. In the presence of ASD and its comorbidities, risperidone was most frequently prescribed.