Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives

Cakir B., Ulucay A., DOĞRUER D. S., Isimer A., Sahin M.

FARMACO, cilt.54, ss.846-851, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0014-827x(99)00111-1
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.846-851
  • Gazi Üniversitesi Adresli: Evet

Özet

Thirteen 3-substituted benzothiazolone derivatives have been synthesized. Their chemical structures have been elucidated by IR and NMR spectral data and by elemental analyses. Among these compounds, 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}morpholine (5b); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}-4-benzylpiperidine (5c); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}-4-phenylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazolone (Sk); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others. (C) 1999 Elsevier Science S.A. All rights reserved.