Effects of nutritional status on serum fetuin-A level

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Icer M. A., Yıldıran H.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, cilt.60, sa.11, ss.1938-1946, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 60 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10408398.2019.1631751
  • Dergi Adı: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, SportDiscus, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1938-1946
  • Anahtar Kelimeler: Fetuin-A, nutritional status, nutrient intake, obesity, curcumin, resveratrol, FATTY LIVER-DISEASE, ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A, CHRONIC KIDNEY-DISEASE, INSULIN-RESISTANCE, VASCULAR CALCIFICATION, CIRCULATING FETUIN, IN-VIVO, CARDIOVASCULAR RISK, ALCOHOL-CONSUMPTION, COFFEE CONSUMPTION
  • Gazi Üniversitesi Adresli: Evet

Özet

Fetuin-A is a glycoprotein structured molecule which is mostly released by the liver. As a multifunctional protein, fetuin-A has positive effects on health such as calcification, cardiovascular diseases and tumor development processes with various mechanisms, whereas it plays a negative role in the processes of obesity, diabetes and fatty liver disease. There are a large number of studies reporting that serum fetuin-A levels are affected by several dietary factors. It is reported in some of these studies that several nutrients increase fetuin-A release, while some others have adverse effects. It is put forward that some nutrients such as dairy products, curcumin, niacin, palmitate, coffee and alcohol consumption decrease fetuin-A level, and dietary omega-3 fatty acids intake may increase fetuin-A concentration. In addition, it is indicated that high blood glucose levels increase hepatic fetuin-A release by activating extracellular signal-regulated kinase 1/2 enzymes and increased plasma free fatty acids do the same effect by increasing NF-B-K activity. Despite these studies in the literature, there is not any review evaluating fetuin-A, chronic diseases and nutrition together. Therefore, in this study, the relationship between serum fetuin levels and some diseases and the effects of nutrients on fetuin A levels were investigated with possible mechanisms.